Pyridine Nucleotides in Developing Rat Liver

Streptozotocin: depression of mouse liver pyridine nucleotides.

phenomenon readily prevented by nicotinamide pretreatment (21). This communication deals with the changes in liver NAD and reduced nicotinamide adenine dinucleotide (NADH) con centrations over a 48-hour period following the single intra venous administration of Streptozotocin. These effects are cor related with the measurement of drug concentration in serum and the acid-soluble fraction of live...

Metabolism of pyridinium precursors of pyridine nucleotides in perfused rat liver.

The uptake and metabolism of nicotinic acid, nicotinamide, and quinolinic acid at physiological concentrations by perfused rat liver have been studied. At a level of 400 mpmoles per liver, nicotinic acid was a more effective precursor of NAD than was nicotinamide. Labeled NAD in the liver reached maximum levels 10 min after nicotinic acid was added to the perfusate. When nicotinamide was the su...

Pyridine nucleotides in erythrocyte metabolism.

The stability of pyridine nucleotides.

Diphosphopyridine nucleotide and triphosphopyridine nucleotide when used in appropriate enzyme systems become exceedingly useful reagents for the measurement of almost any biochemical substance. A companion paper describes procedures for measuring each of the pyridine nucleotides, whether in the oxidized or reduced form, at concentrations as low as 1O-g M and in amounts as small as lo-l5 moles ...

Hydroperoxides can modulate the redox state of pyridine nucleotides and the calcium balance in rat liver mitochondria.

When rats are fed a selenium-deficient diet, the glutathione peroxidase activity in liver mitochondria decreases within 5 weeks to 0-6% of that of control animals fed on a diet supplemented with 0.5 ppm of selenium as sodium selenite. Analysis of the temperature dependence of energy-linked Ca(2+) uptake by means of Arrhenius plots reveals two breaks (at around 11 degrees C and 24 degrees C) in ...